The aim of this search was to formulate and evaluate of Bisoprolol hemifumarate buccal delivery systems. Several tablet formulae were produced by using carboxy methyl cellulose (CMC), polyvinyl pyrrolidone (PVP K30, PVP K90), polyethylene glycol (PEG 4000, PEG 6000), microcrystalline cellulose (Avicel 101, Avicel 102), mannitol and lactose. Drug- Excepients interaction was characterized by DSC analysis. The prepared tablet formulae were evaluated according to their crushing strength, disintegration time, friability, and content uniformity, in vitro drug release using USP dissolution tester and bioavailability study in albino rabbits. All tablet formulae had acceptable hardness, friablility and short disintegrating time. Tablet formula 3 containing (PVP K30 and mannitol) gave the highest drug concentration in rabbits plasma in comparison to other formulae and oral commercial formula.
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